Galatasaray and Real Madrid looked fairly evenly-matched after a first half in the group B game that saw an exchange of goals and a red card that sent off Madrid defender Sergio Ramos.
However, Galatasaray fell apart in the second half, blasted by a constant stream of goals that pulled the score away to 4-1 ten minutes before the final whistle.
The Lions now await the last stand against Juventus, their final chance to catch a last-16 ticket. They will qualify provided that they win and fourth-place Copenhagen lose against Real Madrid, who secured a first-place qualification after tonight's victory.
In the first match of the group stage, Real Madrid had smashedGalatasaray by 6-1 in Turk Telekom Arena, Istanbul, where Portuguese attacker Cristiano Ronaldo had scored a hat-trick.
Goals: Galatasaray - Umut Bulut (39'),Real Madrid - Gareth Bale (37'), Alvaro Arbeloa (63'), Isco (81')