Trabzonspor are ninth in Turkey's Super Lig on 13 points while Gaziantepspor sit a place below due to goal difference.
The Black Sea coast side's Belgian right-back Luis Pedro Cavanda is suspended while his obvious replacement, Jose Bosingwa, is injured.
Kick-off is at 9.45 p.m. local time (1845GMT) at the Huseyin Avni Aker Stadium in Trabzon.
The other Wednesday games see Bursaspor host Medicana Sivasspor and Kayserispor welcome Caykur Rizespor.
Medicana Sivasspor will be aiming to climb out of the relegation zone after losing to Trabzonspor at the weekend. The club sacked manager Sergen Yalcin after that game and appointed ex-Kayserispor boss Okan Buruk.
Bursaspor are sitting mid-table in 11th spot.
The match at Bursa's Ataturk Stadium kicks off at 7 p.m. local time (1600GMT).
Kayserispor and Caykur Rizespor are both propping up the bottom of the table. The match at Kadir Has Stadium in Kayseri starts at 7 p.m. local time (1600GMT).
At the top of the table, Fenerbahce and Galatasaray are playing catch-up with Istanbul rivals Besiktas, who are four points ahead.
Fenerbahce play away at Osmanlispor in Ankara on Thursday. The game at Osmanli Stadium kicks off at 7 p.m. (1600GMT).
Galatasaray host bottom club Eskisehirspor at the Turk Telekom Arena on Thursday. Kick-off is at 9.45 p.m. local time (1845GMT).
Besiktas face Kasimpasa on Friday in a fixture that sees the league's highest-scoring club, Besiktas, face the side that has conceded the least goals.
The match at Basaksehir Fatih Terim Stadium in Istanbul starts at 9.45 p.m. (1845GMT).
Super Lig matches will be played on Oct. 28, 29 and 30 due to Sunday's general election.
Fixtures:
Wednesday:
Kayserispor vs Caykur Rizespor
Bursaspor vs Medicana Sivasspor
Trabzonspor vs Gaziantepspor
Thursday:
Mersin Idmanyurdu vs Medipol Basaksehir
Osmanlispor vs Fenerbahce
Galatasaray vs Eskisehirspor
Friday:
Akhisar Belediyespor vs Antalyaspor
Torku Konyaspor vs Genclerbirligi
Besiktas vs Kasimpasa
